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KMID : 0358419940370122335
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Korean Journal of Obstetrics and Gynecology
1994 Volume.37 No. 12 p.2335 ~ p.2342
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Measuring Cytokine Levels in the Amniotic Fluid of the Women with Preterm Labor and their Associations with Intrauterine Infections
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서경
김세광/조재성/박용원/이윤호/김석영/이국
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Abstract
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Subclinical intrauterine infection was suggested as a cause of idiopathic preterm labor. Four groups of 66 pregnant women were studied. Women in the midtrimester of pregnancy undergoing genetic amniocentesis were studied as a preterm without
labor
group. Women with preterm labor were also studied. Term pregnant women undergoing repeat cesarean section were included as a term without labor group, Women with term labor group were also included in the study. Amniotic fluid was obtained
through
amniocentesis. The fluid was culturd for aerobic and anaerobic bacterias. After centrifugation an aliquot of amniotic fluid was frozen(-70℃) for further analysis. Interleukin-1(IL-1) and interleukin-6(IL-6) levels were measured by enzyme
immunoassay.
Glucose levels in the amniotic fluid were measured by hexokinase method. Placentas were examined for histologic chorioamninitis after delivery.
Only two women with term labor showed positive amniotic fluid culture. Glucose levels were lower in the amniotic fluid of term pregnant women than perterm pregnant women, IL-1 level in the amniotic fluid were increased over 290pg/ml in 2 case of
term
labor group. IL-6 were found in all samples of amniotic fluid. The levels were increased in the women having either preterm or term labor.
Il-6 levels in the amniotic fluid were proportionally increased according to the degree of the cervical dilatation. The results suggested that the increased level IL-6 was a result of labor and/or cervical dilatation rather than a cause of
intrauterine
infection evoking preterm labor. Histologic chorioamnionits were increased in the placenta of both preterm labor group and term labor group. The incidence rates of histologic choreioamnionitis were not statistically different among groups.
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KEYWORD
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